This guide supplies the most recent updates on the key challenges of bridging massive bone defects, where choices vary from autografts, “tissue engineered bone”, biomaterials (hydroxyapatite, polycaprolactone and third technology biomaterials) to prostheses. Emphasis has been made on bone tissue engineering, the current state-of-the-artwork on this area, problems encountered with cell culture expertise, scaffolds and bone progress factors (together with genomics) and using gene remedy for the applying of bone growth factors.
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